INTRA OPERATIVE EFFECT OF INTRATHECAL HYPERBARIC BUPIVACAINE WITH MIDAZOLAM AND HYPERBARIC BUPIVACAINE ALONE IN LOWER LIMB AND LOWER ABDOMINAL SURGERIES

Abstract
Spinal anaesthesia is effective in the management of perioperative pain which extends into the initial post-operative period. In order to maximize intraoperative pain free period numerous techniques and newer drugs have been tried. In this study, the anesthetic properties of 12.5 mg of 0.5% hyperbaric bupivacaine with 0.4 ml of normal saline and 12.5 mg of 0.5% hyperbaric bupivacaine with 2 mg of midazolam given intrathecally were compared. A hundred ASA physical status I and II patients, posted for various elective lower limb and lower abdominal surgeries were studied. The patients were divided into two groups of fifty each:
Group A – Received 0.5% hyperbaric bupivacaine 12.5 mg + 0.4 ml of Normal saline
Group B – Received 0.5% hyperbaric bupivacaine 12.5 mg + 2 mg of midazolam.
Addition of 2 mg of midazolam to hyperbaric bupivacaine does not alter the onset and level of sensory and motor block. The time taken for two segment regression was significantly prolonged in Group B (Group A – 78.9; Group B 87.2min).The time taken for maximum sensory blockade was significantly prolonged in Group B(Group A –7.4min; Group B – 5.5min). More number of the mean arterial pressure changes from baseline values varied from 6.76% for patients in group B compared with 5.41% group A. there was 8% fall in the mean pulse rate from the baseline in group B compared to 9.7% in group A.
With the above findings it is evident that the use of 2mg of intrathecal midazolam as an adjuvant to hyperbaric bupivacaine in lower limb and lower abdominal surgeries is beneficial in several aspects and scored over the use of hyperbaric bupivacaine alone without side effects.

2016040210.INTRA OPERATIVE EFFECT OF INTRATHECAL HYPERBARIC BUPIVACAINE WITH MIDAZOLAM AND HYPERBARIC BUPIVACAINE ALONE IN LOWER LIMB

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