Comparative study of Visual Inspection after acetic acid and Lugol’s iodine (VIA, VILI) versus combined Pap smear with visual inspection after acetic acid and Lugol’s iodine for screening of cancer cervix

Abstract
Back ground and objective
Cancer of cervix is a leading cause of morbidity and mortality in women world wide. So there is a need to develop an effective screening test to curb the disease, which should have good sensitivity and specificity. The present study is to compare the effectiveness of visual inspection after acetic acid and visual inspection after Lugol’s iodine as an adjunct test for Pap smear to improve its sensitivity and specificity.
Material and methods
This is a prospective study in which 50 women were screened. First Pap smear was taken followed by VIA, VILI. If positive in visual inspection methods, cervical biopsy is taken.
Results
Of 50 women, 21 had Pap as normal. Of 21, 19 were
negative for VIA, VILI. 2 women positive for both VIA,VILI. 27 had inflammatory smear. Of these 12 were positive for VIA, VILI.one shows dysplasia in Pap and histology shows chronic nonspecific cervicitis. two women who showed dysplasia in histology of these one had inflammatory smear in Pap and 1 had dysplasia in Pap also. These two were positive for VILI but one negative in VIA. Sensitivity of Pap, VIA, VILI individually were 58.6%, 38.46%, 42.85% respectively. Specificity of these 3 tests individually is 93.3%, 71.3%, 86.36% respectively. But sensitivity of Pap when combined with VIA, VILI is 100% and specificity is 80%.
Conclusion
The present study showed that Pap smear when combined with VIA, VILI had 100% sensitivity but with no improvement in specificity.

2016040215,Comparative study of Visual Inspection after acetic acid and Lugol’s iodine (VIA, VILI) versus combined Pap smear…pdf.

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