The viruses in the family, Geminiviridae are the most devastating pathogen infecting plants.  Among the seven genera within the family Geminiviridae, Mastrevirus and Begomovirus are primarily the most destructive.  However, their codon usage analysis is not examined and hence its role in geminivirus host range evolution remains unrevealed.  In this study, a detailed comparative analysis was performed using species of Maize streak virus (MSV) and Tomato leaf curl virus (ToLCV).  Our results suggest the possible interaction of mutational pressure and natural selection.  Correspondence analyses indicate that the evolution of MSV and ToLCV is independent of their geographical location.  Hence, we emphasize the role of codon usage pattern of these viruses in their evolution.

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